Botulinum neurotoxin is widely used for the treatment of central and peripherical neurological conditions. Initially used to treat strabismus, over the years its use has been expanded also to spasticity and other neurological disorders. This review summarizes the evidence from the published literature regarding its effect on neuropathic pain. Almost all investigations were performed using onabotulinum toxin type A (BoNT/A). Most studies provided positive results, even though toxin formulation, dose, dilution, injection techniques, and sites are heterogeneous across studies. Future larger, high-quality, specifically designed clinical trials are warranted to confirm botulinum neurotoxin efficacy in neuropathic pain.

中文翻译：

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肉毒杆菌神经毒素治疗神经性疼痛。

肉毒杆菌神经毒素被广泛用于治疗中枢和周围神经系统疾病。最初用于治疗斜视，多年来，其用途也已扩展到痉挛和其他神经系统疾病。这篇综述总结了已发表文献对神经性疼痛的影响的证据。几乎所有调查都是使用A型肉毒杆菌毒素（BoNT / A）进行的。即使研究中毒素的配方，剂量，稀释，注射技术和部位不同，大多数研究也提供了积极的结果。将来需要进行更大范围的高质量，专门设计的临床试验，以确认肉毒杆菌神经毒素在神经性疼痛中的功效。