The concept of adult hippocampal neurogenesis (AHN) has been widely accepted, and a large number of studies have been performed in rodents using modern experimental techniques, which have clarified the nature and developmental processes of adult neural stem/progenitor cells, the functions of AHN, such as memory and learning, and its association with neural diseases. However, a fundamental problem is that it remains unclear as to what extent AHN actually occurs in humans. The answer to this is indispensable when physiological and pathological functions of human AHN are deduced from studies of rodent AHN, but there are controversial data on the extent of human AHN. In this review, studies on AHN performed in rodents and humans will be briefly reviewed, followed by a discussion of the studies in non-human primates. Then, how data of rodent and non-human primate AHN should be applied for understanding human AHN will be discussed.

中文翻译：

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从啮齿动物和非人类灵长类动物的研究中了解人类成年海马神经发生的真实状态


成体海马神经发生（AHN）的概念已被广泛接受，并利用现代实验技术在啮齿动物身上进行了大量研究，阐明了成体神经干/祖细胞的性质和发育过程、AHN的功能，例如记忆和学习，及其与神经疾病的关联。然而，一个根本问题是，目前尚不清楚 AHN 在人类中实际发生的程度。当从啮齿动物AHN的研究中推导出人类AHN的生理和病理功能时，这个问题的答案是必不可少的，但关于人类AHN的程度存在争议的数据。在这篇综述中，将简要回顾在啮齿类动物和人类中进行的 AHN 研究，然后讨论在非人类灵长类动物中进行的研究。然后，将讨论如何应用啮齿动物和非人类灵长类动物 AHN 的数据来理解人类 AHN。