Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family includes 28 isoforms activated by physical and chemical stimuli, such as temperature, pH, osmotic pressure, and noxious stimuli. Recently, it has been shown that TRP channels are also directly or indirectly activated by reactive oxygen species. Oxidative stress plays an essential role in neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, and TRP channels are involved in the progression of those diseases by mechanisms involving changes in the crosstalk between Ca2+ regulation, oxidative stress, and production of inflammatory mediators. TRP channels involved in nociception include members of the TRPV, TRPM, TRPA, and TRPC subfamilies that transduce physical and chemical noxious stimuli. It has also been reported that pain is a complex issue in patients with Alzheimer’s and Parkinson’s diseases, and adequate management of pain in those conditions is still in discussion. TRPV1 has a role in neuroinflammation, a critical mechanism involved in neurodegeneration. Therefore, some studies have considered TRPV1 as a target for both pain treatment and neurodegenerative disorders. Thus, this review aimed to describe the TRP-dependent mechanism that can mediate pain sensation in neurodegenerative diseases and the therapeutic approach available to palliate pain and neurodegenerative symptoms throughout the regulation of these channels.

中文翻译：

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TRP 通道在神经退行性疾病相关疼痛中的作用

瞬时受体电位 (TRP) 是在不同组织（包括心脏、肺和脑）的非兴奋性和兴奋性细胞中表达的阳离子通道。TRP 通道家族包括由物理和化学刺激（例如温度、pH、渗透压和有害刺激）激活的 28 种亚型。最近，研究表明TRP通道也可以直接或间接地被活性氧激活。氧化应激在阿尔茨海默病和帕金森病等神经退行性疾病中起着重要作用，TRP 通道通过涉及 Ca2+ 调节、氧化应激和炎症介质产生之间串扰变化的机制参与这些疾病的进展。参与伤害感受的 TRP 通道包括转导物理和化学伤害性刺激的 TRPV、TRPM、TRPA 和 TRPC 亚家族的成员。另据报道，对于阿尔茨海默病和帕金森病患者来说，疼痛是一个复杂的问题，对这些疾病的疼痛进行适当的治疗仍在讨论中。TRPV1 在神经炎症中发挥作用，神经炎症是神经变性的一种关键机制。因此，一些研究将 TRPV1 视为疼痛治疗和神经退行性疾病的靶标。因此，本综述旨在描述在神经退行性疾病中介导痛觉的 TRP 依赖性机制，以及在这些通道的调节过程中可用于缓解疼痛和神经退行性症状的治疗方法。