ABSTRACT

Objective: This brief report reviews the literature on moderators of treatment for adolescent depression. Treatment moderators can help to guide the process of personalizing intervention to individual patient characteristics.

Method: We conducted a systematic search in PsycInfo and PubMed. We also reviewed references of previous reviews and searched for moderator analyses conducted secondary to published efficacy studies.

Results: We review 27 studies that address the following categories of moderators: demographics, severity indices, comorbidity, contextual factors, history of abuse or trauma, and cognition and coping. We found limited evidence that demographic, contextual, or cognitive variables consistently moderated treatment for adolescent depression. There was some indication of moderation by race/ethnicity, presence of some comorbid disorders, greater depression severity, and a history of trauma.

Conclusion: Our review found inconsistent findings across studies, likely due to the strong impact of predictors relative to moderators and limited statistical power. More research using innovative statistical approaches is necessary before treatment tailoring can be an empirically-based process.

摘要

目的：这份简短的报告回顾了有关青少年抑郁症治疗调节剂的文献。治疗主持人可以帮助指导针对个体患者特征的个性化干预过程。

方法：我们在 PsycInfo 和 PubMed 中进行了系统搜索。我们还审查了先前评论的参考文献，并搜索了继已发表的疗效研究之后进行的调节分析。

结果：我们回顾了 27 项针对以下调节因素类别的研究：人口统计学、严重程度指数、合并症、背景因素、虐待或创伤史，以及认知和应对。我们发现有限的证据表明人口统计学、情境或认知变量始终可以调节青少年抑郁症的治疗。有一些迹象表明种族/民族、存在一些合并症、更严重的抑郁症和创伤史。

结论：我们的审查发现跨研究的结果不一致，可能是由于预测因素相对于调节因素的强烈影响和有限的统计能力。在治疗定制成为基于经验的过程之前，需要使用创新的统计方法进行更多研究。