Background: Aza-steroids are an important class of compounds because of their numerous biological activities. The hetero steroids have different hydrogen bonding ability and hydrophobicity in comparison to steroids.

Materials and Methods: Microwave-induced synthesis of a novel type of hybrid hetero-steroid amine conjugates, following Ugi-four component reactions of steroidal amines with alanine and valine methyl esters as amino acid residues is described. Specifically, hetero-steroid-amino acid conjugate based on D-ring fused hetero steroidal amine, hetero-steroid-amino acid conjugate based on A-ring hetero steroidal amine, and hetero-steroidamino acid conjugate based on B-ring hetero steroidal amine are synthesized.

Results and Discussion: The yield of the products under microwave-induced process was considerably higher than that obtained by the conventional method. In contrast to the conventional method for the synthesis of these molecules, microwave-induced method has several advantages.

Conclusion: These include rapid reaction, a superior yield of the product, minimum side reaction, and economical microwave-induced process.

背景：氮杂类固醇是一类重要的化合物，因为它们具有多种生物活性。与类固醇相比，杂类固醇具有不同的氢键能力和疏水性。

材料和方法：描述了在甾族胺与作为氨基酸残基的丙氨酸和缬氨酸甲酯的 Ugi-四组分反应之后，微波诱导合成一种新型杂杂甾体胺缀合物。具体地，基于D环稠合杂甾胺的杂甾体-氨基酸缀合物、基于A环杂甾胺的杂甾体-氨基酸缀合物和基于B环杂甾胺的杂甾体氨基酸缀合物是合成的。

结果与讨论：微波诱导过程的产物收率明显高于常规方法所得产物。与合成这些分子的常规方法相比，微波诱导方法具有几个优点。

结论：这些包括快速反应、高产率、最少的副反应和经济的微波诱导过程。