Current Organic Synthesis ( IF 1.7 ) Pub Date : 2020-11-30 , DOI: 10.2174/1570179417666200825164654 Preetismita Borah 1 , Biswa Mohan Sahoo 2 , Vhatkar Dattatraya Shivling 1 , Bimal Krishna Banik 3
Background: Aza-steroids are an important class of compounds because of their numerous biological activities. The hetero steroids have different hydrogen bonding ability and hydrophobicity in comparison to steroids.
Materials and Methods: Microwave-induced synthesis of a novel type of hybrid hetero-steroid amine conjugates, following Ugi-four component reactions of steroidal amines with alanine and valine methyl esters as amino acid residues is described. Specifically, hetero-steroid-amino acid conjugate based on D-ring fused hetero steroidal amine, hetero-steroid-amino acid conjugate based on A-ring hetero steroidal amine, and hetero-steroidamino acid conjugate based on B-ring hetero steroidal amine are synthesized.
Results and Discussion: The yield of the products under microwave-induced process was considerably higher than that obtained by the conventional method. In contrast to the conventional method for the synthesis of these molecules, microwave-induced method has several advantages.
Conclusion: These include rapid reaction, a superior yield of the product, minimum side reaction, and economical microwave-induced process.
中文翻译:
微波诱导的 Ugi-四组分反应:新的杂-类固醇-氨基酸缀合物的合成。
背景:氮杂类固醇是一类重要的化合物,因为它们具有多种生物活性。与类固醇相比,杂类固醇具有不同的氢键能力和疏水性。
材料和方法:描述了在甾族胺与作为氨基酸残基的丙氨酸和缬氨酸甲酯的 Ugi-四组分反应之后,微波诱导合成一种新型杂杂甾体胺缀合物。具体地,基于D环稠合杂甾胺的杂甾体-氨基酸缀合物、基于A环杂甾胺的杂甾体-氨基酸缀合物和基于B环杂甾胺的杂甾体氨基酸缀合物是合成的。
结果与讨论:微波诱导过程的产物收率明显高于常规方法所得产物。与合成这些分子的常规方法相比,微波诱导方法具有几个优点。
结论:这些包括快速反应、高产率、最少的副反应和经济的微波诱导过程。