COVID-19 has become a substantial lethal disease worldwide, and early diagnosis is a significant concern for this virus. Currently, RT-PCR is being used worldwide for the detection of this virus with human to human transmission. Furthermore, the recent develop biosensor leading to others diagnosis approach but being invasive are painful and time taking. Another possibility can be protein-based biomarkers as an application of biosensors for detection and early diagnostics. Considering the other approach, that is, microfluidics-based biosensor, though being a non-invasive method, will be restricting virus transmission. This review commences with the recent develop biosensor for Covid-19 detection and listing down the available biomarkers with their secretion range comparison of normal to COVID-19 patients through clinical analysis in china and concludes with the future approach for the diagnosis.

中文翻译：

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基于蛋白质的生物标志物，用于非侵入性Covid-19检测。

在世界范围内，COVID-19已成为一种严重的致死性疾病，因此对该病毒的早期诊断非常重要。目前，RT-PCR正在全球范围内用于通过人与人之间的传播来检测这种病毒。此外，最近开发的生物传感器导致了其他诊断方法，但具有侵入性，这是痛苦的，并且花费时间。另一种可能是基于蛋白质的生物标志物，作为生物传感器在检测和早期诊断中的应用。考虑另一种方法，即基于微流体的生物传感器虽然是一种非侵入性方法，但却会限制病毒的传播。