The case of twins born with genes modified by He Jiankui highlights the need for international governance of germline gene editing (GGE). This article proposes a global framework that utilizes "ordo-responsibilities." This is a pragmatic ethical approach open to pluralism and grounded in principles of human dignity and human rights. Ordo-responsibility is pragmatic in (1) accepting generally available values on a global level (e.g., human dignity, human rights) and (2) seeking achievable implementation. Genetic science is practiced globally in ways that transcend borders. As such, its practice must take account of the vast complexity of cultural, ethical, legal, and anthropological convictions. Here, we explain the basic structure of an appropriate rule-finding process, outline a possible pathway toward an international framework, and discuss minimal requirements that are needed in that endeavor. We thereby contribute to the debate on how to govern genome-editing technologies and GGE globally.

中文翻译：

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生殖细胞基因编辑的Ordo责任。

由何建奎修饰的基因出生的双胞胎的案例凸显了对种系基因编辑（GGE）进行国际治理的必要性。本文提出了一个利用“任务责任”的全局框架。这是一种务实的道德态度，对多元主义开放，以人的尊严和人权原则为基础。鄂尔多斯责任组织在以下方面是务实的：（1）在全球范围内接受普遍可用的价值观（例如，人的尊严，人权）；（2）寻求可实现的实施。遗传科学以超越国界的方式在全球范围内进行实践。因此，其实践必须考虑到文化，伦理，法律和人类学信念的巨大复杂性。在这里，我们解释了适当的规则查找过程的基本结构，概述了通向国际框架的可能途径，并讨论该工作所需的最低要求。因此，我们为有关如何在全球范围内管理基因组编辑技术和GGE的辩论做出了贡献。