The adverse influences of triphenyltin (TPT) on the aquatic system have been of great concern due to their widespread use and ubiquity in water environment, although it has been prohibited as antifouling coatings. In the present study, we investigated the developmental toxicity of TPT on zebrafish embryos by exposure to different concentrations (0, 1, 10, and 100 ng/l) from 2-h post-fertilization (hpf). Some parameters of developmental abnormalities (hatching, survival, body length, and malformation) were recorded, as well as the expression of several genes involved in the retinal development and growth hormone/insulin-like growth factor (GH/IGF) axis. Our results showed that TPT exposure induced developmental toxicity, including growth inhibition, malformation, and the dysregulation of gene expression levels related to the retinal development and GH/IGF axis. Thus, our data indicated that environmental exposure of TPT could induce developmental toxicity in zebrafish embryos, and those parameters could extend our understanding of the adverse effects of TPT on aquatic organisms.

三苯基锡（TPT）对水生系统的不利影响由于在水环境中的广泛使用和普遍存在而备受关注，尽管它已被禁止作为防污涂料。在本研究中，我们通过受精后2小时（hpf）暴露于不同浓度（0、1、10和100 ng / l），研究了TPT对斑马鱼胚胎的发育毒性。记录了发育异常的一些参数（孵化，存活，体长和畸形），以及参与视网膜发育和生长激素/胰岛素样生长因子（GH / IGF）轴的几个基因的表达。我们的结果表明，暴露于TPT会诱发发育毒性，包括生长抑制，畸形，以及与视网膜发育和GH / IGF轴相关的基因表达水平失调。因此，我们的数据表明，TPT的环境暴露可以在斑马鱼胚胎中诱导发育毒性，而这些参数可以扩展我们对TPT对水生生物不利影响的理解。