In this study, we synthesised the zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory and antinociceptive potentials against the different inflammation and pain induced mice model. The synthesised zinc oxide nanoparticles were characterised by UV, SEM, XRD and FTIR techniques. The anti-nociceptive effects of V. amygdalina were examined by different stimuli e.g. acetic acid, glutamate, capsaicin, and formalin-induced nociception in mice. The anti-inflammatory effects of synthesised zinc oxide nanoparticles were assessed by air sack assessment and the level of inflammatory cytokines were studied. The muscle tension of animals were studied through open field assessment. The present study exhibited proficient antinociceptive and anti-inflammatory actions of the synthesised Zinc oxide nanoparticles from V. amygdalina. The sormulated zinc oxide nanoparticles were appreciably reduced the acetic acid, glutamate, capsaicin, and formalin-induced nociceptive responses in mice. Further the zinc nanoparticles were exhibited the potent anti-inflammatory actions via reducing the inflammatory response and pro-inflammatory cytokines level in the mice. In conclusion, the findings of this study proved the beneficial effects of zinc oxide nanoparticles from V. amygdalina against the different pain and inflammation-induced mice. Hence, it was clear that the zinc nanoparticles from V. amygdalina could be promising antinociceptive and anti-inflammatory agent in the future.

中文翻译：

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从扁桃Vernonia合成的氧化锌纳米颗粒在小鼠模型中显示出抗炎和镇痛作用。

在这项研究中，我们合成了杏仁核Vernonia的氧化锌纳米颗粒，并针对不同的炎症和疼痛诱发小鼠模型评估了其抗炎和抗伤害感受的潜力。通过UV，SEM，XRD和FTIR技术对合成的氧化锌纳米粒子进行了表征。通过不同的刺激，例如乙酸，谷氨酸，辣椒素和福尔马林诱导的小鼠伤害感受，来检测扁桃酸模的抗伤害作用。通过气囊评估了合成氧化锌纳米粒子的抗炎作用，并研究了炎性细胞因子的水平。通过野外评估研究动物的肌肉张力。本研究显示了从扁桃体中合成的氧化锌纳米颗粒的有效的抗伤害感受和消炎作用。加热后的氧化锌纳米颗粒可明显降低小鼠体内的乙酸，谷氨酸，辣椒素和福尔马林诱导的伤害反应。此外，锌纳米颗粒通过减少小鼠中的炎症反应和促炎细胞因子水平表现出有效的抗炎作用。总而言之，这项研究的结果证明了扁桃体氧化锌纳米颗粒对不同疼痛和炎症所致小鼠的有益作用。因此，很明显，扁桃体弧菌的锌纳米颗粒将来可能成为有希望的抗伤害性和消炎剂。此外，锌纳米颗粒通过减少小鼠中的炎症反应和促炎细胞因子水平表现出有效的抗炎作用。总而言之，这项研究的结果证明了扁桃体氧化锌纳米颗粒对不同疼痛和炎症所致小鼠的有益作用。因此，很明显，扁桃体弧菌的锌纳米颗粒将来可能成为有希望的抗伤害性和消炎剂。此外，锌纳米颗粒通过减少小鼠中的炎症反应和促炎细胞因子水平表现出有效的抗炎作用。总而言之，这项研究的结果证明了扁桃体氧化锌纳米颗粒对不同疼痛和炎症所致小鼠的有益作用。因此，很明显，扁桃体弧菌的锌纳米颗粒将来可能成为有希望的抗伤害性和消炎剂。