Abstract

We determined that a genetic haplotype increased the risk of hyperuricaemia and it interacted with lifestyle factors, including nutrients in 28,445 middle-aged Koreans. ABCG2_rs2231142, PKD2_rs2725220 and SLC2A9_rs3733591 were selected from GWAS based on hyperuricaemia (≥7 mg/dL; p = 6.88E-42, 1.56E-26 and 1.01E-20, respectively). Hyperuricaemia and gout were elevated by 3.93- and 3.23-fold, respectively, by the minor alleles as compared with the major alleles of the haplotype of the selected 3 SNPs after adjusting for covariates. The haplotype significantly interacted with alcohol, chicken and processed meat intakes, and smoking status in the hyperuricaemia risk (p = 0.002–0.007). Minor alleles of the haplotype had an association with hyperuricaemia as compared with major alleles particularly in high intakes of alcohol (2g/day), chicken (6.3g/day), and processed meat (3g/day) and smokers. In conclusion, people carrying minor alleles of the haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 should avoid diets high in chicken and processed meat, alcohol drinking, and cigarette smoking to protect against hyperuricaemia risk.

摘要

我们确定遗传单倍型增加了高尿酸血症的风险，并且它与生活方式因素相互作用，包括 28,445 名韩国中年人的营养素。ABCG2 _rs2231142、PKD2 _rs2725220 和SLC2A9 _rs3733591 选自基于高尿酸血症的 GWAS（≥7 mg/dL；分别为p  = 6.88E-42、1.56E-26 和 1.01E-20）。在调整协变量后，与所选 3 个 SNP 单倍型的主要等位基因相比，次要等位基因导致的高尿酸血症和痛风分别升高了 3.93 倍和 3.23 倍。单倍型与酒精、鸡肉和加工肉类摄入量以及高尿酸血症风险中的吸烟状况显着相互作用（p = 0.002–0.007）。与主要等位基因相比，单倍型的次要等位基因与高尿酸血症相关，尤其是在大量饮酒（2 克/天）、鸡肉（6.3 克/天）和加工肉类（3 克/天）和吸烟者中。总之，携带SLC2A9 _rs3733591、PKD2 _rs2725220 和ABCG2 _rs2231142单倍型的次要等位基因的人应避免高含量鸡肉和加工肉类的饮食、饮酒和吸烟，以防止高尿酸血症风险。