Abstract Increasing interest in the treatment of human disease by means of targeted radionuclide-based therapies requires an accurate understanding of achievable yields and quantification of realisable degrees of purity. Important studies within a more extensive Coordinated Research Project of the International Atomic Energy Agency (IAEA CRP) have included in-depth assessments and evaluations of all available measured cross-section data for ten nuclear reactions leading to the formation of 131Cs, 131Ba, 225Ac, 225Ra, 227Th, 227Ac, 230U and 230Pa for various on-going and proposed therapeutic applications in nuclear medicine. Equivalent studies were also undertaken of possible reactions to produce the 178W/low-spin 178mTa generator system that has been clinically applied in diagnosis by means of SPECT - these particular cross-section studies and recommendations are included in this paper for completeness. All available measured data have been critically reviewed and assessed to produce statistically consistent datasets. Selected datasets have been fitted by a least-squares method with Pade approximations of variable order to evaluate the production cross sections and corresponding uncertainties. New measurements have been made in some instances, and reported data have been adjusted to accommodate new nuclear decay or monitor reaction data which altered the original reported quantities adversely. Insufficient measured data are available in many cases to permit a reliable evaluation of cross sections, and these instances are discussed. Recommended therapeutic radionuclide production reaction data and their uncertainties are available on the Web page of the IAEA Nuclear Data Section at www-nds.iaea.org/radionuclides/ and also at the IAEA medical portal www-nds.iaea.org/medportal/ .

中文翻译：

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用于生产选定治疗性放射性核素的推荐核数据

摘要 对通过基于放射性核素的靶向疗法治疗人类疾病的兴趣日益增加，需要准确了解可实现的产量和可实现纯度的量化。国际原子能机构（IAEA CRP）更广泛的协调研究项目中的重要研究包括对导致形成 131Cs、131Ba、225Ac、10 种核反应的所有可用测量横截面数据的深入评估和评价。 225Ra、227Th、227Ac、230U 和 230Pa 用于核医学中各种正在进行和提议的治疗应用。还对生产 178W/低自旋 178mTa 发电机系统的可能反应进行了等效研究，该系统已通过 SPECT 临床应用于诊断——这些特定的横截面研究和建议包含在本文中以求完整性。所有可用的测量数据都经过严格审查和评估，以产生统计上一致的数据集。选定的数据集已通过最小二乘法与可变阶次的 Pade 近似进行拟合，以评估生产横截面和相应的不确定性。在某些情况下进行了新的测量，并调整了报告的数据以适应新的核衰变或监测反应数据，这些数据对原始报告的数量产生了不利影响。在许多情况下没有足够的测量数据来允许对横截面进行可靠的评估，并且讨论了这些情况。建议的治疗性放射性核素生产反应数据及其不确定性可在原子能机构核数据科的网页 www-nds.iaea.org/radionuclides/ 以及原子能机构医疗门户网站 www-nds.iaea.org/medportal/ 上获得。