The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under metal-free and oxidant-free conditions,Organic Chemistry Frontiers

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The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under metal-free and oxidant-free conditions
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-09-10 , DOI: 10.1039/d0qo00909a
Jia Xu _{1,

2,

3,

4} , Zhao Yang _{4,

5,

6,

7} , Jiawei Hua _{1,

2,

3,

4} , Yang Lin _{1,

2,

3,

4} , Mixue Bian _{1,

2,

3,

4} , Yuguang Li _{4,

8,

9} , Chengkou Liu _{1,

2,

3,

4} , Wei He _{1,

2,

3,

4} , Zheng Fang _{1,

2,

3,

4} , Kai Guo _{1,

2,

3,

4,

10}

Affiliation

An efficient and green electrochemical continuous-flow approach has been developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones through the sulfonylation of alkenes with sulfonylhydrazides. The reaction proceeds in a continuous-flow electrolytic cell under metal-free and oxidant-free conditions. A series of activated alkenes were suitable for this system, and the corresponding products were obtained in moderate to good yields. Moreover, reaction scale-up was smoothly achieved using the electrochemical continuous-flow system without changing the reaction conditions.

中文翻译：

在无金属和无氧化剂条件下由N-烷基-N-甲基丙烯酰基苯甲酰胺连续流电合成4-（磺酰基甲基）异喹啉-1,3（2H，4H）-二酮

通过烯烃与磺酰肼的磺酰化反应，已开发出一种高效且绿色的电化学连续流方法，用于合成4-（磺酰基甲基）异喹啉-1,3（2 H，4 H）-二酮。反应在无金属和无氧化剂的条件下在连续流电解池中进行。一系列的活化烯烃适用于该系统，并且以中等至良好的产率获得了相应的产物。此外，使用电化学连续流系统可在不改变反应条件的情况下顺利实现反应放大。

更新日期：2020-10-13

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