Since graphene was first isolated in 2004, research related to graphene-based 2D material for surface plasmon resonance (SPR) biosensor applications has increased. Recently, other types of 2D materials such as Transition Metal Dichalcogenides have also been investigated. This 2D material has exceptional optical and electronic properties and can be utilized to improve the performance of biosensors. The performance of SPR biosensors can be determined based on their sensitivity and detection accuracy (DA). To find out the sensitivity and DA, simulation approach can be done. In this paper, we perform SPR simulations on monolayer and multilayer structures of 2D material, namely graphene, graphene oxide, molibdenum disulfida, and tungsten diselenide. In addition, we also investigated the sensitivity and DA of SPR biosensors on hybrid structures. The results obtained indicate that the use of 2D material can increase the sensitivity of the SPR up to 5 times when compared to conventional structures. Of the four types of 2D material investigated, GO is the material with the best accuracy. If the SPR biosensor performance is determined based on the FOM value, the best performance is owned by the GO-based SPR structure with a sensitivity of 151.87 deg/RIU and DA 0.22 deg-1.

自 2004 年首次分离石墨烯以来，与用于表面等离子体共振 (SPR) 生物传感器应用的基于石墨烯的 2D 材料相关的研究有所增加。最近，还研究了其他类型的 2D 材料，例如过渡金属二硫属化物。这种二维材料具有卓越的光学和电子特性，可用于提高生物传感器的性能。SPR 生物传感器的性能可以根据其灵敏度和检测精度 (DA) 来确定。为了找出灵敏度和DA，可以进行模拟方法。在本文中，我们对二维材料（即石墨烯、氧化石墨烯、二硫化钼和二硒化钨）的单层和多层结构进行 SPR 模拟。此外，我们还研究了 SPR 生物传感器对混合结构的灵敏度和 DA。获得的结果表明，与传统结构相比，使用二维材料可以将 SPR 的灵敏度提高多达 5 倍。在所研究的四种 2D 材料中，GO 是精度最高的材料。如果根据 FOM 值确定 SPR 生物传感器性能，则最佳性能属于基于 GO 的 SPR 结构，其灵敏度为 151.87 deg/RIU 和 DA 0.22 deg-1。