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Supramolecular medical antibacterial tissue adhesive prepared based on natural small molecules
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-10 , DOI: 10.1039/d0bm01101k Junying Chen 1, 2, 3, 4, 5 , Tian Yuan 2, 6, 7, 8, 9 , Zuozhen Liu 1, 2, 3, 4, 5
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-10 , DOI: 10.1039/d0bm01101k Junying Chen 1, 2, 3, 4, 5 , Tian Yuan 2, 6, 7, 8, 9 , Zuozhen Liu 1, 2, 3, 4, 5
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In the field of biomedicine, tissue bio-adhesives require the use of polymer materials with integrated functions to meet changing practical applications. However, the currently available tissue glues cannot balance mechanical properties and biocompatibility. Inspired by the conversion of lipoic acid from small molecular biological sources into high-performance supramolecular polymeric materials, thioctic acid (TA) was modified and polyethylene glycol diacrylate (PEGDA) was introduced. Successfully constructed a dry gel with antibacterial effect and promote infection for wound regeneration. The prepared modified lipoic acid is mixed with PEGDA, melted under mild heating and self-assembled, and then directly extruded on both sides of the wound. It quickly cures at 37 °C and firmly adheres to both sides of the wound. The material exhibits good processability and rapid self-healing ability due to the cross-linked structure of the internal disulfide bonds and thioether bonds. In addition, the characteristics of TA make the prepared xerogels have good tissue adhesion and good antibacterial properties. This work proposes an innovative material with mechanical strength and biocompatible tissue glue, which provides broad prospects for application in wound treatment.
中文翻译：
基于天然小分子制备的超分子医用抗菌组织胶
在生物医学领域，组织生物粘合剂需要使用具有集成功能的聚合物材料来满足不断变化的实际应用。但是，当前可用的组织胶不能平衡机械性能和生物相容性。受硫辛酸从小分子生物学来源转化为高性能超分子聚合物材料的启发，对硫辛酸（TA）进行了改性，并引入了聚乙二醇二丙烯酸酯（PEGDA）。成功构建具有抗菌作用并促进伤口再生的感染性干燥凝胶。将制备的改性硫辛酸与PEGDA混合，在温和的加热下熔化并自组装，然后直接挤出在伤口的两侧。它在37°C时迅速固化，并牢固地粘附在伤口的两侧。由于内部二硫键和硫醚键的交联结构，该材料具有良好的加工性能和快速的自修复能力。另外，TA的特性使得所制备的干凝胶具有良好的组织粘附性和良好的抗菌性能。这项工作提出了一种具有机械强度和生物相容性组织胶的创新材料，为伤口治疗的应用提供了广阔的前景。
更新日期：2020-10-02
中文翻译：
基于天然小分子制备的超分子医用抗菌组织胶
在生物医学领域，组织生物粘合剂需要使用具有集成功能的聚合物材料来满足不断变化的实际应用。但是，当前可用的组织胶不能平衡机械性能和生物相容性。受硫辛酸从小分子生物学来源转化为高性能超分子聚合物材料的启发，对硫辛酸（TA）进行了改性，并引入了聚乙二醇二丙烯酸酯（PEGDA）。成功构建具有抗菌作用并促进伤口再生的感染性干燥凝胶。将制备的改性硫辛酸与PEGDA混合，在温和的加热下熔化并自组装，然后直接挤出在伤口的两侧。它在37°C时迅速固化，并牢固地粘附在伤口的两侧。由于内部二硫键和硫醚键的交联结构，该材料具有良好的加工性能和快速的自修复能力。另外，TA的特性使得所制备的干凝胶具有良好的组织粘附性和良好的抗菌性能。这项工作提出了一种具有机械强度和生物相容性组织胶的创新材料，为伤口治疗的应用提供了广阔的前景。
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