Orthosiphon aristatus (Blume) Miq. is traditionally used for wound healing in South East Asia and scientifically proven for its antidiabetic potential. Wounds due to diabetes, especially diabetic foot ulcer (DFU), always involve a complicated healing process. The present work aims to review the information on the rationale of the phytochemicals from O. aristatus in promoting DFU healing. The findings showed that the DFU healing potential of O. aristatus was characterized by a reduction in the blood glucose level, mainly attributed to the significant concentration of constituents such as caffeic acid, rosmarinic acid, and sinensetin in the plant extract. These phytochemicals possibly induce insulin secretion and sensitivity, improve the lipid profile, and stimulate glucose uptake. Furthermore, the healing effect may also be contributed to the antioxidant, anti-inflammatory, and antihyperglycemic properties of the plant. The roles of phytochemicals have been systematically postulated in the 4 phases of the healing process. Moreover, no adverse toxic sign or abnormality has been reported upon oral administration of the plant extract. This suggests that O. aristatus extract could be a potential diabetic wound healing phytomedicine for further preclinical and clinical studies.

Orthosiphon aristatus（Blume）。传统上用于东南亚的伤口愈合，并具有抗糖尿病潜力，并经过科学证明。由糖尿病引起的伤口，尤其是糖尿病足溃疡（DFU），总是涉及复杂的愈合过程。目前的工作旨在审查有关信息科学的信息从O.aristatus促进DFU愈合植物化学物质。研究结果表明，DFU治疗的潜在O. aristatus其特征是血糖水平降低，这主要归因于植物提取物中大量浓度的成分，例如咖啡酸，迷迭香酸和芥子素。这些植物化学物质可能会诱导胰岛素分泌和敏感性，改善脂质分布，并刺激葡萄糖摄取。此外，愈合效果还可以有助于植物的抗氧化，抗炎和抗高血糖特性。已在康复过程的四个阶段中系统地假定了植物化学物质的作用。此外，口服给予植物提取物未见不良毒性迹象或异常。这表明O. aristatus 提取物可能是潜在的糖尿病伤口愈合植物药，可用于进一步的临床前和临床研究。