当前位置: X-MOL 学术Mult. Scler. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Depression is associated with disconnection of neurotransmitter-related nuclei in multiple sclerosis
Multiple Sclerosis Journal ( IF 4.8 ) Pub Date : 2020-09-10 , DOI: 10.1177/1352458520948214
Matteo Martino, Paola Magioncalda, Mohamed Mounir El Mendili, Amgad Droby, Swetha Paduri, Simona Schiavi, Maria Petracca, Matilde Inglese

BACKGROUND Depression is frequently associated with multiple sclerosis (MS). However, the biological background underlying such association is poorly understood. OBJECTIVE Investigating the functional connections of neurotransmitter-related brainstem nuclei, along with their relationship with white matter (WM) microstructure, in MS patients with depressive symptomatology (MS-D) and without depressive symptomatology (MS-nD). METHODS Combined resting-state functional magnetic resonance imaging (fMRI) and diffusion-weighted MRI (dMRI) study on 50 MS patients, including 19 MS-D and 31 MS-nD patients, along with 37 healthy controls (HC). Main analyses performed are (1) comparison between groups of raphe nuclei (RN)-related functional connectivity (FC); (2) correlation between RN-related FC and whole brain dMRI-derived fractional anisotropy (FA) map; and (3) comparison between groups of FA in the RN-related WM area. RESULTS (1) RN-related FC was reduced in MS-D when compared to MS-nD and HC; (2) RN-related FC positively correlated with FA in a WM cluster mainly encompassing thalamic/basal ganglia regions, including the fornix; and (3) FA in such WM area was reduced in MS-D. CONCLUSION Depressive symptomatology in MS is specifically associated to a functional disconnection of neurotransmitter-related nuclei, which in turn may be traced to a distinct spatial pattern of WM alterations mainly involving the limbic network.

中文翻译:

抑郁症与多发性硬化症中神经递质相关核的断开有关

背景抑郁症经常与多发性硬化症(MS)有关。然而,人们对这种关联背后的生物学背景知之甚少。目的研究神经递质相关脑干核的功能连接,以及它们与白质 (WM) 微观结构的关系,在患有抑郁症状 (MS-D) 和无抑郁症状 (MS-nD) 的 MS 患者中。方法 对 50 名 MS 患者(包括 19 名 MS-D 和 31 名 MS-nD 患者)以及 37 名健康对照(HC)进行静息态功能磁共振成像 (fMRI) 和弥散加权 MRI (dMRI) 联合研究。进行的主要分析是 (1) 中缝核 (RN) 相关功能连接 (FC) 组之间的比较;(2) RN相关FC与全脑dMRI衍生的分数各向异性(FA)图的相关性;(3) RN 相关 WM 区域中 FA 组之间的比较。结果 (1) 与 MS-nD 和 HC 相比,MS-D 中 RN 相关的 FC 减少;(2) RN 相关 FC 与 WM 集群中的 FA 正相关,主要包括丘脑/基底神经节区域,包括穹窿;(3) 在 MS-D 中,此类 WM 区域的 FA 减少。结论 MS 的抑郁症状与神经递质相关核的功能性断开特别相关,这反过来又可以追溯到 WM 改变的独特空间模式,主要涉及边缘网络。(3) 在 MS-D 中,此类 WM 区域的 FA 减少。结论 MS 中的抑郁症状与神经递质相关核的功能性断开特别相关,这反过来又可以追溯到 WM 改变的独特空间模式,主要涉及边缘网络。(3) 在 MS-D 中,此类 WM 区域的 FA 减少。结论 MS 中的抑郁症状与神经递质相关核的功能性断开特别相关,这反过来又可以追溯到 WM 改变的独特空间模式,主要涉及边缘网络。
更新日期:2020-09-10
down
wechat
bug