The high incidence of alcoholic poisoning in Indonesia is caused by the use of methanol as a surrogate ingredient of nonconforming alcohol. The product of methanol metabolism is toxic to the liver. Ranitidine has been studied as an antidote to reduce the effect of methanol toxicity. The present study aimed to assess the effect of ranitidine administration on the liver damage of Wistar rats with acute methanol intoxication. This research was an experimental study with randomized and posttest-only control group design. A total of 24 male Wistar rats divided into four groups, each consisting of six Rats. The control group (K0) served as a reference normal value. The control group (K1) was intoxicated with methanol 7 g/kg body weight (b.w.) through rat gavage tube. Treatment groups were intoxicated with methanol and 15 minutes after that, Ranitidine (30 mg/kg b.w. (P1) or 60 mg/kg b.w. (P2)) was given intraperitoneally. Ranitidine administration was proven to protect the liver tissue from damage due to methanol intoxication as was indicated from the histopathological examination. Ranitidine with dose 60 mg/kg b.w. is better in reducing the degree of liver tissue damage in acute methanol intoxication rats.

印度尼西亚酒精中毒事件的高发是由于使用甲醇作为不合格酒精的替代成分造成的。甲醇代谢产物对肝脏有毒害作用。雷尼替丁已被研究作为减轻甲醇毒性影响的解毒剂。本研究旨在评估雷尼替丁对急性甲醇中毒 Wistar 大鼠肝损伤的影响。这项研究是一项实验研究，采用随机和仅后测对照组设计。总共24只雄性Wistar大鼠分为4组，每组6只大鼠。对照组（K0）作为参考正常值。对照组(K1)通过大鼠灌胃管灌胃甲醇7 g/kg体重(bw)。治疗组用甲醇中毒，15分钟后腹腔给予雷尼替丁（30 mg/kg bw（P1）或60 mg/kg bw（P2））。组织病理学检查表明，雷尼替丁给药可保护肝组织免受甲醇中毒造成的损伤。 60 mg/kg体重雷尼替丁对减轻急性甲醇中毒大鼠肝组织损伤程度有较好的效果。