Aim:

Bisphenol-A (BPA) is an endocrine disrupting compound and may exacerbate or induce allergic diseases. To the best of our knowledge, there is little evidence regarding the effects of BPA exposure on allergic rhinitis (AR) in children. In the present study, we sought to examine whether exposure to BPA in children is associated with AR.

Methods:

This study was designed as a case controlled clinical study. 140 children diagnosed as allergic rhinitis and 140 healthy children as control group were recruited. BPA, interleukin-4, interleukin-13, total IgE and interferon-gamma levels were determined. Skin prick tests were performed in patient group. Total nasal symptom score and ARIA classification were used to predict disease severity.

Results:

Serum IL-4, IgE and BPA levels of children with allergic rhinitis were found to be significantly higher than the control group. BPA and IL-4 levels were significantly higher in moderate to severe-persistent group. There was a positive correlation between total nasal symptom scores and Bisphenol A levels in children with allergic rhinitis.

Conclusions:

The present study is the first to observe statistically significant relationship between BPA concentrations and allergic rhinitis in children. Also increased levels of BPA are associated with disease severity.

中文翻译：

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双酚A是儿童过敏性鼻炎的危险因素。

目标：

双酚 A (BPA) 是一种内分泌干扰化合物，可能会加剧或诱发过敏性疾病。据我们所知，几乎没有证据表明 BPA 暴露对儿童过敏性鼻炎 (AR) 的影响。在本研究中，我们试图检查儿童接触 BPA 是否与 AR 相关。

方法：

本研究设计为病例对照临床研究。招募了140名被诊断为过敏性鼻炎的儿童和140名健康儿童作为对照组。测定了 BPA、白细胞介素 4、白细胞介素 13、总 IgE 和干扰素-γ 水平。患者组进行皮肤点刺试验。总鼻部症状评分和 ARIA 分类用于预测疾病严重程度。

结果：

过敏性鼻炎患儿血清IL-4、IgE、BPA水平明显高于对照组。BPA和IL-4水平在中度至重度持续组中显着升高。过敏性鼻炎患儿鼻部症状总分与双酚A水平呈正相关。

结论：

本研究首次观察到 BPA 浓度与儿童过敏性鼻炎之间具有统计学意义的关系。BPA 水平的升高也与疾病的严重程度有关。