Objective. In this study, we aimed to evaluate the executive profile of juvenile myoclonic epilepsy (JME) patients using the Frontal Assessment Battery (FAB) as a bedside screening tool and investigate its association with seizure proximity, family history of epilepsy, and polytherapy/monotherapy with antiepileptic drugs (AEDs). Background. JME patients have deficits in various aspects of executive functions. FAB has proved to be a useful tool for evaluating executive functions in clinical settings. Methods. Thirty-one JME patients and 110 healthy controls (HCs) were enrolled in this study. The participants were assessed using six subsets of FAB, including conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy. Results. Compared to HCs, JME patients showed lower scores in conceptualization, mental flexibility, programming, sensitivity to interference, and total FAB. The number of AEDs (polytherapy versus monotherapy) and duration of time since the last seizure had no significant effect on FAB scores in JME patients. We found significant associations between disease duration and conceptualization, mental flexibility, inhibitory control, and total FAB score only in JME patients with recent seizure. Finally, receiver operating characteristic (ROC) analysis showed area under the curve (AUC) of 0.971 (95% confidence interval (CI): 0.947–0.994) for FAB total score, 0.933 for conceptualization (95% CI: 0.973-894), and 0.836 for mental flexibility (95% CI: 0.921-751). Conclusions. In summary, JME patients had deficits in different aspects of executive functions. FAB is a useful clinical tool for evaluation of executive functions in JME patients.

中文翻译：

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使用正面评估电池评估青少年肌阵挛性癫痫患者的执行功能。

客观。在这项研究中，我们旨在评估青少年肌阵挛性癫痫 (JME) 患者的执行概况，使用额叶评估电池 (FAB) 作为床边筛查工具，并调查其与癫痫发作接近度、癫痫家族史和多药/单药治疗的关系。抗癫痫药物（AEDs）。背景。JME 患者在执行功能的各个方面都有缺陷。FAB 已被证明是评估临床环境中执行功能的有用工具。方法. 31 名 JME 患者和 110 名健康对照 (HC) 参加了这项研究。参与者使用 FAB 的六个子集进行评估，包括概念化、心理灵活性、运动编程、对干扰的敏感性、抑制控制和环境自主性。结果. 与 HC 相比，JME 患者在概念化、心理灵活性、编程、对干扰的敏感性和总 FAB 方面表现出较低的分数。AED 的数量（多药治疗与单药治疗）和自上次癫痫发作以来的持续时间对 JME 患者的 FAB 评分没有显着影响。我们仅在近期癫痫发作的 JME 患者中发现疾病持续时间与概念化、心理灵活性、抑制控制和总 FAB 评分之间存在显着关联。最后，受试者工作特征 (ROC) 分析显示，FAB 总分的曲线下面积 (AUC) 为 0.971（95% 置信区间 (CI)：0.947-0.994），概念化为 0.933（95% CI：0.973-894），心理灵活性为 0.836（95% CI：0.921-751）。结论. 总之，JME 患者在执行功能的不同方面存在缺陷。FAB 是评估 JME 患者执行功能的有用临床工具。