Generalized half-center oscillators with short-term synaptic plasticity,Physical Review E

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Generalized half-center oscillators with short-term synaptic plasticity
Physical Review E ( IF 2.2 ) Pub Date : 2020-09-10 , DOI: 10.1103/physreve.102.032406
V Baruzzi ₁ , M Lodi ₁ , M Storace ₁ , A Shilnikov ₂

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How can we develop simple yet realistic models of the small neural circuits known as central pattern generators (CPGs), which contribute to generate complex multiphase locomotion in living animals? In this paper we introduce a new model (with design criteria) of a generalized half-center oscillator, (pools of) neurons reciprocally coupled by fast/slow inhibitory and excitatory synapses, to produce either alternating bursting or other rhythmic patterns, characterized by different phase lags, depending on the sensory or other external input. We also show how to calibrate its parameters, based on both physiological and functional criteria and on bifurcation analysis. This model accounts for short-term neuromodulation in a biophysically plausible way and is a building block to develop more realistic and functionally accurate CPG models. Examples and counterexamples are used to point out the generality and effectiveness of our design approach.

中文翻译：

具有短期突触可塑性的广义半中心振荡器

我们如何才能开发出称为中枢模式发生器（CPG）的小型神经回路的简单而又现实的模型，这些模型会在动物体内产生复杂的多相运动？在本文中，我们介绍了一种新的模型（具有设计标准），该模型具有广义半中心振荡器，通过快速/缓慢抑制和兴奋性突触相互耦合的神经元（池）产生交替的爆发或其他节律性模式，其特征在于相位滞后，取决于感觉或其他外部输入。我们还将展示如何根据生理和功能标准以及分叉分析来校准其参数。该模型以生物物理上可行的方式解释了短期神经调节作用，并且是开发更现实，功能上更准确的CPG模型的基础。

更新日期：2020-09-10

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