Dengue is an acute febrile disease triggered by dengue virus. Dengue is the widespread and rapidly transmitted mosquito-borne viral disease of humans. Diverse symptoms and diseases due to Dengue virus (DENV) infection ranges from dengue fever, dengue hemorrhagic fever (life-threatening) and dengue shock syndrome characterized by shock, endothelial dysfunction and vascular leakage. Several studies have linked the severity of dengue with the induction of inflammasome. DENV activates the NLRP3-specific inflammasome in DENV infected human patients, mice; specifically, mouse bone marrow derived macrophages (BMDMs), dendritic cells, endothelial cells, human peripheral blood mononuclear cells (PBMCs), keratinocytes, monocyte-differentiated macrophages (THP-1), and platelets. Dengue virus mediated inflammasome initiates the maturation of IL-1β and IL-18, which are critical for dengue pathology and inflammatory response. Several studies have reported the molecular mechanism through which (host and viral factors) dengue induces inflammasome, unravels the possible mechanisms of DENV pathogenesis and sets up the stage for the advancement of DENV therapeutics. In this perspective article, we discuss the potential implications and our understanding of inflammasome mechanisms of dengue virus and highlight research areas that have potential to inhibit the pathogenesis of viral diseases, specifically for dengue.

登革热是由登革热病毒引发的急性发热性疾病。登革热是人类广泛传播和快速传播的蚊媒病毒性疾病。由登革热病毒（DENV）感染引起的多种症状和疾病包括登革热，登革出血热（威胁生命）和以休克，内皮功能障碍和血管渗漏为特征的登革热休克综合征。几项研究将登革热的严重程度与炎性体的诱发联系在一起。DENV激活DENV感染的人类患者，小鼠中的NLRP3特异性炎症小体。具体地说，是小鼠骨髓衍生的巨噬细胞（BMDM），树突状细胞，内皮细胞，人外周血单核细胞（PBMC），角质形成细胞，单核细胞分化的巨噬细胞（THP-1）和血小板。登革热病毒介导的炎症小体启动了IL-1β和IL-18的成熟，对于登革热病理和炎症反应至关重要。几项研究报告了登革热（宿主和病毒因素）诱发炎症小体的分子机制，揭示了登革热致病机理的可能机制，并为登革热疗法的发展奠定了基础。在这篇有远见的文章中，我们讨论了对登革热病毒炎症机制的潜在影响和我们的理解，并重点介绍了可能抑制病毒性疾病（尤其是登革热）发病机理的研究领域。揭示了DENV发病机理的可能机制，并为DENV疗法的发展奠定了基础。在这篇有远见的文章中，我们讨论了对登革热病毒炎症机制的潜在影响和我们的理解，并重点介绍了可能抑制病毒性疾病（尤其是登革热）发病机理的研究领域。揭示了DENV发病机理的可能机制，并为DENV疗法的发展奠定了基础。在这篇有远见的文章中，我们讨论了对登革热病毒炎症机制的潜在影响和我们的理解，并重点介绍了可能抑制病毒性疾病（尤其是登革热）发病机理的研究领域。