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Iron(III)chloride induced synthesis of pyrazolopyridines & quinolines
Synthetic Communications ( IF 1.8 ) Pub Date : 2020-09-10
Nagaraju Medishetti, Ashok Kale, Jagadeesh Babu Nanubolu, Krishnaiah Atmakur

A simple and straightforward protocol has been accomplished for synthesis of pyrazolo[3,4-b]pyridines by reacting 5-amino-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (1) and β-enaminoketones (2) promoted by Iron(III)chloride. This protocol was also able to produce quinolines (5) by the reaction of O-nitrobenzaldehydes and β-enaminoketones. Simple reaction conditions, high compatibility and excellent yields are the advantages of this protocol.



中文翻译:

氯化铁(III)诱导合成吡唑并吡啶和喹啉

通过使5-氨基-1-苯基-3-(三氟甲基)-1H-吡唑-4-甲醛(1)与β-烯酮反应合成吡唑并[3,4- b ]吡啶的简单而直接的方法(2)由三氯化铁促进。该方案还能够通过O-硝基苯甲醛与β-烯酮的反应生成喹啉(5)。简单的反应条件,高的相容性和优异的产率是该方案的优点。

更新日期:2020-09-10
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