Abstract

Background

We investigated the effects and mechanism of swimming on platelet function in mice fed with a high-fat diet.

Material and Methods

Mice were randomly divided into the control group (NC), high-fat group (HF), and high-fat diet combined with swimming group (FE). The FE group swam for 60 min a day, 5 days a week, for 8 weeks.

Results

Compared with the NC group, the HF group had significant weight gain, dyslipidemia, abbreviated bleeding time after tail breakage, increased clot retraction, increased platelet aggregation rate, increased spread of platelets on fibrinogen, and increased pAKT level in platelets. Compared with the HF group, the FE group had lower body weight, improved dyslipidemia, prolonged bleeding time, reduced clot retraction, reduced platelet aggregation rate, decreased spread of platelets on fibrinogen, and decreased pAKT level in platelets.

Conclusions

By inhibiting the level of pAKT in platelets, swimming improves platelet dysfunction in mice fed with a high-fat diet.

中文翻译：

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游泳改善高脂肪饮食小鼠的血小板功能障碍

摘要

背景

我们研究了游泳对喂食高脂肪饮食的小鼠血小板功能的影响和机制。

材料与方法

小鼠随机分为对照组（NC）、高脂组（HF）和高脂饮食联合游泳组（FE）。FE 组每天游泳 60 分钟，每周游泳 5 天，持续 8 周。

结果

与NC组相比，HF组体重明显增加，血脂异常，断尾后出血时间缩短，凝块回缩增加，血小板聚集率增加，血小板在纤维蛋白原上的扩散增加，血小板中pAKT水平增加。与HF组相比，FE组体重减轻，血脂异常改善，出血时间延长，凝块回缩减少，血小板聚集率降低，血小板对纤维蛋白原的扩散减少，血小板中pAKT水平降低。

结论

通过抑制血小板中 pAKT 的水平，游泳改善了喂食高脂肪饮食的小鼠的血小板功能障碍。