Reaction between 4-hydroxy-6-methyl-2H-pyran-2-one and aldehydes with 2-methylpyridine in dioxane under catalyst-free conditions provided a simple and efficient one-pot route for the synthesis of 3-[1-aryl(alkyl)-2-pyridin-2-yl-ethyl]-4-hydroxy-6-methyl-2H-pyran-2-ones. The reaction is characterized by inexpensive and easily available starting materials, the formation of a single product, high yields of biologically active products, and a simple work-up process.

中文翻译：

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催化合成3- [1-芳基（烷基）-2-吡啶-2-基-乙基] -4-羟基-6-甲基-2H-吡喃-2-酮的简单有效的一锅法-免费条件

4-羟基-6-甲基-2H-吡喃-2-酮与醛与2-甲基吡啶在二恶烷中在无催化剂条件下的反应为合成3- [1-芳基（烷基）-2-吡啶-2-基-乙基] -4-羟基-6-甲基-2H-吡喃-2-酮。该反应的特征在于廉价且容易获得的起始原料，单一产物的形成，高生物活性产物的产率以及简单的后处理过程。