Alzheimer’s disease and type 2 diabetes mellitus: A systematic review of proteomic studies,Journal of Neurochemistry

当前位置： X-MOL 学术 › J. Neurochem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Alzheimer’s disease and type 2 diabetes mellitus: A systematic review of proteomic studies
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2020-09-09 , DOI: 10.1111/jnc.15166
Jessica Diniz Pereira ₁ , Vanessa Gomes Fraga ₁ , Anna Luiza Morais Santos ₁ , Maria das Graças Carvalho ₁ , Paulo Caramelli ₂ , Karina Braga Gomes ₁

Affiliation

Similar to dementia, the risk for developing type 2 diabetes mellitus (T2DM) increases with age, and T2DM also increases the risk for dementia, particularly Alzheimer's disease (AD). Although T2DM is primarily a peripheral disorder and AD is a central nervous system disease, both share some common features as they are chronic and complex diseases, and both show involvement of oxidative stress and inflammation in their progression. These characteristics suggest that T2DM may be associated with AD, which gave rise to a new term, type 3 diabetes (T3DM). In this study, we searched for matching peripheral proteomic biomarkers of AD and T2DM based in a systematic review of the available literature. We identified 17 common biomarkers that were differentially expressed in both patients with AD or T2DM when compared with healthy controls. These biomarkers could provide a useful workflow for screening T2DM patients at risk to develop AD.

中文翻译：

阿尔茨海默氏病和2型糖尿病：蛋白质组学研究的系统综述

与痴呆症相似，患2型糖尿病（T2DM）的风险会随着年龄的增长而增加，并且T2DM也会增加痴呆症的风险，尤其是阿尔茨海默氏病（AD）。尽管T2DM主要是一种外周疾病，而AD是一种中枢神经系统疾病，但由于它们是慢性和复杂疾病，它们都具有一些共同的特征，并且都显示出氧化应激和炎症参与其进展。这些特征表明，T2DM可能与AD相关，从而引起了新的3型糖尿病（T3DM）。在这项研究中，我们在现有文献的系统综述的基础上，搜索了AD和T2DM的外周蛋白质组学生物标志物。我们确定了与健康对照组相比在AD或T2DM患者中差异表达的17种常见生物标志物。

更新日期：2020-09-09

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11