Pyrethroids like permethrin have been used as topical formulations for their ectoparasiticidal effects since the 1970s. There are numerous efficacy studies in dogs and livestock animals that indicate a fast spread of pyrethroids after topical administration onto rather confined areas of the skin. Some studies correlate the efficacy against ticks, fleas or lice with concentrations of pyrethroids in hair and, less frequently, stratum corneum samples. It is often stated that lateral transport is responsible for the distribution of the pyrethroids over the body surface. With this review, we attempt to demonstrate evidence for lateral transport of pyrethroids after topical administration in dogs, cattle and sheep and to present data gaps that should be addressed in follow‐up studies.

中文翻译：

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局部应用于兽医物种后拟除虫菊酯的表面分布：对横向运输的影响。

自 1970 年代以来，拟除虫菊酯（如氯菊酯）因其杀体外寄生虫作用而被用作局部制剂。对狗和家畜动物进行的许多功效研究表明，在局部施用到相当有限的皮肤区域后，拟除虫菊酯会迅速扩散。一些研究将对抗蜱、跳蚤或虱子的功效与头发中拟除虫菊酯的浓度相关联，较少见的是角质层样本。人们常说，侧向运输负责拟除虫菊酯在体表上的分布。通过本综述，我们试图证明在狗、牛和羊中局部给药后拟除虫菊酯横向转运的证据，并提出应在后续研究中解决的数据差距。