Engaging thieno[2,3‐b]indole‐2,3‐dione for the efficient synthesis of spiro[indoline‐3,4′‐thiopyrano[2,3‐b]indole] by reaction with N‐substituted isatilidenes,Journal of Heterocyclic Chemistry

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Engaging thieno[2,3‐b]indole‐2,3‐dione for the efficient synthesis of spiro[indoline‐3,4′‐thiopyrano[2,3‐b]indole] by reaction with N‐substituted isatilidenes
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-09-10 , DOI: 10.1002/jhet.4147
Noble V. Thomas ₁ , Vidya Sathi ₁ , Ani Deepthi ₁ , Sruthi Leena ₁ , Sidharth Chopra ₂

Affiliation

A simple and efficient method, proceeding through a new mechanistic pathway, for the synthesis of spiro[indoline‐3,4‐thiopyrano[2.3‐b]indole derivatives have been developed by exploiting the reaction of thieno[2,3‐b]indole‐2,3‐dione with N‐substituted isatilidenes. The compounds synthesized have been screened for antibacterial activity. The generality of the reaction and mechanistic rationale are presented.

中文翻译：

噻吩[2,3-b]吲哚-2,3-二酮与N-取代的异戊二烯反应，可有效合成螺[吲哚啉-3,4'-硫代吡喃并[2,3-b]吲哚]

通过利用噻吩并[2,3-b]吲哚的反应，开发了一种简单有效的方法，通过新的机理途径合成螺[吲哚啉-3,4-硫代吡喃并[2.3-b]吲哚衍生物-2,3-二酮与N-取代的异戊二烯。已经筛选了合成的化合物的抗菌活性。介绍了反应的一般性和机理原理。

更新日期：2020-09-10

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