Bone graft is required in various surgical procedures. Although autograft is the gold standard, it has limited availability. Various compounds have been proposed as alternatives such as biphasic calcium phosphate (BCP), which is the most widely used compound. The newly synthesized microporous sphere‐shaped BCP has the advantage of increasing contact surface, and it can induce the formation of microbone structures. A putty‐type contains the addition of a fluid carrier to the sphere‐shaped BCP and can be easily used for a small orifice large bone defect. To compare the widely used BCP products, new bone formation and residual graft materials (RGM) were evaluated for 6 and 12 weeks in a rabbit calvarial bone defect model. Although existing BCP products and the microporous sphere‐type product did not differ significantly with respect to new bone formation and RGM, the putty‐type product was largely washed out and had low new bone formation at 6 and 12 weeks. Overall, the results suggest that microporous sphere‐shaped BCP showed similar bone formation capability to existing products and was able to maintain higher initial mechanical stability.

中文翻译：

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微孔球形双相磷酸钙在兔颅骨骨缺损模型中的骨形成效果。

各种外科手术都需要骨移植物。尽管自体移植是黄金标准，但它的可用性有限。已经提出了各种化合物作为替代品，例如双相磷酸钙 (BCP)，它是最广泛使用的化合物。新合成的微孔球形BCP具有增加接触面的优点，可以诱导微骨结构的形成。腻子型包含在球形 BCP 中添加流体载体，可轻松用于小孔大骨缺损。为了比较广泛使用的 BCP 产品，我们在兔颅骨缺损模型中评估了 6 周和 12 周的新骨形成和残余移植材料 (RGM)。虽然现有的 BCP 产品和微孔球型产品在新骨形成和 RGM 方面没有显着差异，但腻子型产品在 6 周和 12 周时大部分被洗掉并且新骨形成较低。总体而言，结果表明微孔球形 BCP 显示出与现有产品相似的骨形成能力，并且能够保持更高的初始机械稳定性。