当前位置：
X-MOL 学术
›
ChemistrySelect
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Synthesis and Evaluation of New 2‐Mercaptomethyl Benzimidazole Scaffolds as Potential Antibacterial, Antioxidant and Cytotoxic Agents
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-09-10 , DOI: 10.1002/slct.202002822 Mohamed E. Khalifa 1
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-09-10 , DOI: 10.1002/slct.202002822 Mohamed E. Khalifa 1
Affiliation
|
Novel series of benzimidazole derivatives are developed based on the key compound 2‐mercaptomethyl benzimidazole 1. The reactivity of the precursor compound 1 towards nucleophilic reagents enabled us to produce new series with expected bioactivity. The synthesized benzimidazole scaffolds are structurally authenticated and fully characterized by their spectral properties. They exhibit antimicrobial efficiency against selected pathogenic bacteria strains (Gram +ve & ‐ve bacteria) using disc diffusion method, the inhibition clear zones (mm) and MIC are recorded as well. The compounds are also assessed for their cytotoxicity, antioxidant and antitumor activity against HEP−G2 human hepatoma cell line, showing gradient efficiencies related to the chemical structure.
中文翻译：
新型2-巯基甲基苯并咪唑支架的合成和评价作为潜在的抗菌，抗氧化剂和细胞毒性剂
基于关键化合物2-巯基甲基苯并咪唑1开发了一系列新的苯并咪唑衍生物。前体化合物1对亲核试剂的反应性使我们能够生产具有预期生物活性的新系列。合成的苯并咪唑支架在结构上经过鉴定，并通过其光谱特性进行全面表征。它们对选定的病原菌菌株具有抗菌功效（Gram + ve＆‐ve盘扩散法，同时记录抑制清除区（mm）和MIC。还评估了这些化合物对HEP-G2人肝癌细胞系的细胞毒性，抗氧化剂和抗肿瘤活性，显示出与化学结构有关的梯度效率。
更新日期：2020-09-10
中文翻译：
新型2-巯基甲基苯并咪唑支架的合成和评价作为潜在的抗菌，抗氧化剂和细胞毒性剂
基于关键化合物2-巯基甲基苯并咪唑1开发了一系列新的苯并咪唑衍生物。前体化合物1对亲核试剂的反应性使我们能够生产具有预期生物活性的新系列。合成的苯并咪唑支架在结构上经过鉴定，并通过其光谱特性进行全面表征。它们对选定的病原菌菌株具有抗菌功效（Gram + ve＆‐ve盘扩散法，同时记录抑制清除区（mm）和MIC。还评估了这些化合物对HEP-G2人肝癌细胞系的细胞毒性，抗氧化剂和抗肿瘤活性，显示出与化学结构有关的梯度效率。
京公网安备 11010802027423号