DNA vaccination: We report the design, syntheses and bioactivity evaluation of cationic amphiphiles containing mannose‐mimicking di‐shikimoyl‐(DSG) and di‐quinoyl‐(DQG) head groups as well as their control non‐mannosyl (BBG) analogues. We show that direct immunization with the electrostatic complexes of lipid nanoparticles of DSG/p‐CMV‐MART1 induces a long‐lasting protective immune response against B16F10 tumor challenge with remarkable memory response.

中文翻译：

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通过甘露糖受体将 DNA 疫苗体内靶向树突细胞诱导对黑色素瘤的持久免疫

DNA 疫苗接种：我们报告了含有模拟甘露糖的二莽草酰基 (DSG) 和二喹酰基 (DQG) 头基的阳离子两亲物及其对照非甘露糖基 (BBG) 类似物的设计、合成和生物活性评估。我们表明，用 DSG/p-CMV-MART1 脂质纳米颗粒的静电复合物直接免疫可诱导针对 B16F10 肿瘤攻击的持久保护性免疫反应，并具有显着的记忆反应。