A bifunctional squaramide catalyzed asymmetric conjugate addition of nitroalkanes to trifluoromethylated 3-methyleneoxindoles was developed, and a range of trifluoromethyl containing oxindole derivatives were obtained with generally high yields and enantioselectivities. The nitro functionality and oxindole scaffold in the corresponding products are versatile building blocks that readily enable many further valuable transformations.

中文翻译：

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硝基烷向三氟甲基化的3-亚甲基吲哚的有机催化对映选择性共轭加成反应

开发了双官能方酰胺催化的硝基烷烃向三氟甲基化的3-亚甲基吲哚的不对称共轭加成反应，并以高收率和对映选择性获得了一系列含三氟甲基的羟吲哚衍生物。相应产品中的硝基官能团和羟吲哚支架是通用的构建基块，可轻松实现许多其他有价值的转化。