Abstract We present a robust and flexible approach for the fabrication of chemical micropatterns of controllable dimension, based on the deposition of plasma-polymerized (pp) polymer films by using atmospheric-pressure plasma printing. In particular, the deposition of oxygen-rich organic pp. films, aimed at the immobilization of biomolecules, is discussed. The maskless, fast and eco-friendly depositions present a line resolution between 50 μm to 250 μm, and a film thickness between 70 and 600 nm depending on the applied process parameters. Physico-chemical properties –such as morphology and functional groups– can be tailored to adjust a certain chemical platform suitable for multiple biosensing and microfluidic applications. The generated pp. films are characterized by a saturated aliphatic-branched polymer structure with incorporated oxygen functionalities and a sufficient level of stability in aqueous environment. Furthermore, pp. films provide an excellent reactivity towards amine-bearing molecules, which is exemplarily shown for the binding of acriflavine, a fluorescent dye.

中文翻译：

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等离子打印 - 用于生物传感和微流体应用的功能性聚合物涂层的直接局部图案化

摘要 我们提出了一种稳健而灵活的方法，用于制造尺寸可控的化学微图案，基于使用大气压等离子印刷沉积等离子体聚合 (pp) 聚合物薄膜。特别讨论了富氧有机聚丙烯薄膜的沉积，旨在固定生物分子。根据应用的工艺参数，无掩模、快速且环保的沉积具有 50 μm 至 250 μm 的线分辨率和 70 至 600 nm 的薄膜厚度。物理化学特性——如形态和官能团——可以定制，以调整适合多种生物传感和微流体应用的特定化学平台。生成的pp。薄膜的特点是饱和的脂肪族支链聚合物结构，结合了氧官能团，在水性环境中具有足够的稳定性。此外，pp. 薄膜对含胺的分子提供了极好的反应性，这在与荧光染料吖啶黄的结合方面得到了示例性的证明。