Nanomedicine is at a crossroads: with relatively few success stories in terms of clinical translation despite more and more research on increasingly sophisticated nanomaterials, it is important to consider whether we are on the right track. Indeed, it is crucial that we address the fact that while considerable efforts are being made to overcome barriers to translation from the bench to the clinic, scientists are still struggling to decipher fundamental aspects of nanomaterial interactions with biological systems. We believe that a key to the successful adoption of nanomedicines in oncology and beyond lies in a deeper understanding of underlying biological processes and in decoding interactions between engineered nanomaterials and biological systems. Here we provide an overview of progress in nanomedicine during the past 5 years.

纳米医学正处于十字路口：尽管对越来越复杂的纳米材料的研究越来越多，但在临床翻译方面的成功案例相对较少，因此重要的是要考虑我们是否走上了正确的道路。确实，至关重要的是，我们要解决这样一个事实：尽管人们正在做出巨大的努力来克服从实验台到临床的翻译障碍，但科学家们仍在努力解释纳米材料与生物系统相互作用的基本方面。我们认为，在肿瘤学及其他领域成功采用纳米药物的关键在于对基础生物学过程的深入了解以及对工程纳米材料与生物系统之间相互作用的解码。在这里，我们概述了过去5年中纳米医学的进展。