Obesity is a widespread problem within modern society, serving to increase the risk of cardiovascular, metabolic, and neurodegenerative disorders. Peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator 1 α (PGC1α) play a key role in the regulation of cellular energy metabolism and is implicated in the pathology of these diseases. This study examined the association between polymorphisms of the PPARG and PPARGC1A genes and individual variability in weight loss in response to physical activity intervention. 39 obese Ukrainian women (44.4 ± 7.5 years, BMI > 30.0 kg/m²) undertook a 3-month fitness program whilst following a hypocaloric diet (~ 1500 cal). Anthropometric and biochemical measurements took place before and after the program. Single nucleotide polymorphisms within or near PPARG (n = 94) and PPARGC1A (n = 138) were identified and expression of PPARG mRNA was measured via reverse transcription and amplification. The association between DNA polymorphisms and exercise-induced weight loss, initial body mass, biochemistry and PPARG expression was determined using one-way analysis of variance (ANOVA). The present intervention induced significant fat loss in all participants (total fat: 40.3 ± 5.3 vs 36.4 ± 5.7%; P < 0.00001). Only one polymorphism (rs17650401 C/T) within the PPARGC1A gene was found to be associated with fat loss efficiency after correction for multiple testing, with T allele carriers showing the greatest reduction in body fat percentage (2.5-fold; P = 0.00013) compared to non-carriers. PPARGC1A (rs17650401) is associated with fat loss efficiency of the fitness program in obese women. Further studies are warranted to test whether this variation is associated with fat oxidation.

肥胖是现代社会中普遍存在的问题，其增加了心血管，代谢和神经退行性疾病的风险。过氧化物酶体增殖物激活受体γ（PPARγ）和PPARγ共激活因子1α（PGC1α）在调节细胞能量代谢中起关键作用，并与这些疾病的病理学有关。这项研究检查了PPARG和PPARGC1A基因的多态性与体重减轻对体育锻炼的反应个体差异之间的关系。39名乌克兰肥胖妇女（44.4±7.5岁，BMI> 30.0 kg / m ²）在接受低热量饮食（约1500卡路里）的同时进行了3个月的健身计划。在该计划之前和之后进行人体测量和生化测量。鉴定出PPARG（n = 94）和PPARGC1A（n = 138）内或附近的单核苷酸多态性，并通过逆转录和扩增测量PPARG mRNA的表达。DNA多态性与运动引起的体重减轻，初始体重，生物化学和PPARG表达之间的关联使用方差单向分析（ANOVA）确定。目前的干预措施导致所有参与者的脂肪大量减少（总脂肪：40.3±5.3与36.4±5.7％；P <0.00001）。在多次测试校正后，仅发现PPARGC1A基因内的一种多态性（rs17650401 C / T）与减脂效率相关，与等位基因T携带者相比，体脂百分比降低幅度最大（2.5倍；P  = 0.00013）非承运人。PPARGC1A（rs17650401）与肥胖女性健身计划的减肥效率有关。有必要进行进一步的研究以测试这种变化是否与脂肪氧化有关。