Using multiplex analysis, we performed a comparative study of cytokine and growth factor production by human umbilical cord tissue-derived multipotent mesenchymal stromal cells (UC-MSC) cultured under standard conditions and in the presence of human umbilical cord blood serum (UCBS). It was found that the secretion of most studied molecules, including well-known inductors of regeneration HGF, G-CSF, GM-CSF, and VEGF by UCMSC considerably increased in the presence of 5% UCBS. The use of UCBS allows not only obtaining xenogenic-free cellular and cell-free therapeutic products, but also increasing the secretion of most biologically active molecules capable of stimulating repair processes.

中文翻译：

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人脐带组织衍生的多能间充质基质细胞在脐带血血清中表现出最大的分泌活性

使用多重分析，我们对在标准条件下和人脐带血清 (UCBS) 存在下培养的人脐带组织来源的多能间充质基质细胞 (UC-MSC) 产生的细胞因子和生长因子进行了比较研究。结果发现，在 5% UCBS 存在下，UCMSC 分泌的大多数研究分子，包括众所周知的再生诱导剂 HGF、G-CSF、GM-CSF 和 VEGF，显着增加。UCBS 的使用不仅可以获得无异种细胞和无细胞治疗产品，而且还可以增加大多数能够刺激修复过程的生物活性分子的分泌。