Stress-induced cytotoxicity caused by xenobiotics and endogenous metabolites induces the production of reactive oxygen species and often results in damage to cellular components such as DNA, proteins, and lipids. The cytochrome P450 (CYP) family of enzymes are most abundant in hepatocytes, where they play key roles in regulating cellular stress responses. We aimed to determine the effects of the antioxidant compound, methylsulfonylmethane (MSM), on oxidative stress response, and study the CYP3A gene expression in fetal horse hepatocytes.

中文翻译：

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甲基磺酰甲烷会影响胎儿马肝细胞的氧化应激和CYP3A93表达。

由外源生物和内源性代谢物引起的应激诱导的细胞毒性诱导了活性氧的产生，并经常导致对DNA，蛋白质和脂质等细胞成分的损害。细胞色素P450（CYP）酶家族在肝细胞中含量最高，在调节细胞应激反应中起关键作用。我们旨在确定抗氧化剂化合物甲磺酰甲烷（MSM）对氧化应激反应的影响，并研究CYP3A基因在胎马肝细胞中的表达。