Biobased thermosensitive polyrotaxanes constructed by polymerization of cyclodextrin-triterpenoid inclusion complexes,Polymer Chemistry

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Biobased thermosensitive polyrotaxanes constructed by polymerization of cyclodextrin-triterpenoid inclusion complexes
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020-09-09 , DOI: 10.1039/d0py00966k
Jiawei Li _{1,

2,

3,

4} , Xia Yu _{1,

2,

3,

4} , Yiran Zhao _{1,

2,

3,

4} , Hao Zhang _{1,

2,

3,

4} , Min-Hui Li _{1,

2,

3,

4,

5} , Jun Hu _{1,

2,

3,

4}

Affiliation

In this work, three cyclodextrin-based polyrotaxanes (CD-based PRs) with alternating multiblock structures were constructed by polymerization of inclusion complexes in a convenient tandem way, where an inclusion complex of a natural glycyrrhetinic acid (GA) derivative and γ-CD polymerized with three PEG-dicarbonates, respectively, followed by capping with amino-β-CD. During the formation of CD-based PRs, only a small amount of γ-CD slipped off and around 90% of GA units on the guest polymer were complexed with γ-CD. Note that although the three CD-based PRs had similar molecular weights of ∼50 000 Da, the decrease of the PEG length (from 4000 to 600 Da) led to an enhancement of the structural rigidity and the variation in the hydrophilic–lipophilic balance (HLB). In this case, the sizes of the assembled spherical micelles and the reversible phase transition behaviors were effectively regulated by the molecular rigidity and HLB. Our biocompatible CD-based PRs with precise controllable performance may lead to further exploration of thermosensitive materials.

中文翻译：

通过聚合环糊精-三萜类化合物包合物构建的生物基热敏聚轮烷

在这项工作中，通过以便捷的串联方式聚合包合配合物，构建了具有交替多嵌段结构的三种具有交替多嵌段结构的环糊精基聚轮烷，其中天然甘草次酸（GA）衍生物和γ-CD的包合配合物进行了聚合。分别用三个PEG-二碳酸酯，然后用氨基β-CD封端。在基于CD的PR的形成过程中，只有少量的γ-CD脱落，并且客体聚合物上约90％的GA单元与γ-CD络合。请注意，尽管三种基于CD的PR的分子量相似，约为50,000 Da，但PEG长度的减少（从4000到600 Da）导致结构刚度的提高和亲水亲脂平衡的变化（ HLB）。在这种情况下，分子刚度和HLB有效地调节了组装好的球形胶束的尺寸和可逆的相变行为。我们基于生物相容性CD的PR具有精确的可控性能，可能会导致对热敏材料的进一步探索。

更新日期：2020-09-21

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