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Lithocaldehydes A and B, polyketones from the deep sea-derived fungus Phomopsis lithocarpus FS508.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-09-09 , DOI: 10.1039/d0ob01674h Huibo Liu 1 , Zhaoming Liu 2 , Haohua Li 2 , Haibo Tan 3 , Qingbo Zhang 4 , Dongli Li 5 , Hongxin Liu 2 , Weimin Zhang 2
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-09-09 , DOI: 10.1039/d0ob01674h Huibo Liu 1 , Zhaoming Liu 2 , Haohua Li 2 , Haibo Tan 3 , Qingbo Zhang 4 , Dongli Li 5 , Hongxin Liu 2 , Weimin Zhang 2
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Lithocaldehydes A (1) and B (2), a pair of novel diastereoisomers possessing an unprecedented 6/6/5/5/6 highly-fused ring system forming an earring-like skeleton, were isolated from the deep sea-derived fungus Phomopsis lithocarpus FS508. The structures of 1 and 2 were fully characterized and established through extensive spectroscopic interpretations and ECD calculations. Moreover, compounds 1 and 2 were shown to be promising antibiotics, exhibiting potent antifungal activities that are comparable to those of the positive control nystatin.
中文翻译：
石松醛 A 和 B，来自深海真菌拟茎点霉 FS508 的聚酮。
从深海真菌拟茎点霉中分离得到石草醛 A ( 1 ) 和 B ( 2 ) ，这是一对新型非对映异构体，具有前所未有的 6/6/5/5/6 高度稠合环系统，形成耳环状骨架石果FS508。通过广泛的光谱解释和 ECD 计算， 1和2的结构得到了充分的表征和确定。此外，化合物1和2被证明是有前途的抗生素，表现出与阳性对照制霉菌素相当的有效抗真菌活性。
更新日期：2020-09-30
中文翻译：
石松醛 A 和 B，来自深海真菌拟茎点霉 FS508 的聚酮。
从深海真菌拟茎点霉中分离得到石草醛 A ( 1 ) 和 B ( 2 ) ，这是一对新型非对映异构体，具有前所未有的 6/6/5/5/6 高度稠合环系统，形成耳环状骨架石果FS508。通过广泛的光谱解释和 ECD 计算， 1和2的结构得到了充分的表征和确定。此外，化合物1和2被证明是有前途的抗生素，表现出与阳性对照制霉菌素相当的有效抗真菌活性。
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