Community-acquired urinary tract infection (CA-UTI) could be caused by endogenous or exogenous routes. To show this relationship, we investigated molecular fingerprints and genotypes of paired Enterococcus faecalis isolated from the urine of symptomatic patients and their fecal samples. Out of the studied patients, 63 pairs of E. faecalis isolates were obtained simultaneously from their urine and feces samples. All the strains were sensitive to vancomycin, linezolid, nitrofurantoin, and daptomycin (MIC value: ≤ 4 µg/ml), while resistance to tetracycline (urine: 88.9%; stool: 76.2%) and minocycline (urine: 87.3%, stool: 71.4%) was detected in most of them. The most common detected virulence genes were included efbA, ace, and gelE. RAPD-PCR and PFGE analyses showed the same patterns of molecular fingerprints between paired of the isolates in 26.9% and 15.8% of the patients, respectively. Similarity of E. faecalis strains between the urine and feces samples confirmed the occurrence of endogenous infection via contamination with colonized bacteria in the intestinal tract. Carriage of a complete virulence genotype in the responsible strains was statistically in correlation with endogenous UTI, which shows their possible involvement in pathogenicity of uropathogenic E. faecalis strains.

中文翻译：

---

社区获得性尿路感染患者粪便和尿液样本中粪肠球菌分离株的遗传相关性。

社区获得性尿路感染 (CA-UTI) 可能由内源性或外源性途径引起。为了证明这种关系，我们研究了从有症状患者的尿液及其粪便样本中分离出的配对粪肠球菌的分子指纹和基因型。在研究的患者中，从他们的尿液和粪便样本中同时获得了 63 对粪肠球菌分离株。所有菌株均对万古霉素、利奈唑胺、呋喃妥因和达托霉素敏感（MIC值：≤4 µg/ml），而对四环素（尿液：88.9%；粪便：76.2%）和米诺环素（尿液：87.3%，粪便： 71.4%）在其中大部分中检测到。最常见的检测到的毒力基因包括 efbA、ace 和 gelE。RAPD-PCR 和 PFGE 分析显示，26 株分离株之间的分子指纹模式相同。分别为 9% 和 15.8% 的患者。尿液和粪便样本之间粪肠球菌菌株的相似性证实了通过肠道中定植细菌的污染发生内源性感染。在负责任的菌株中携带完整的毒力基因型与内源性尿路感染在统计学上相关，这表明它们可能与尿路致病性粪肠球菌菌株的致病性有关。