Chronic immune activation and hyperglycaemia are a hallmark of type 2 diabetes mellitus (T2D) while natural killer (NK) cells are involved in the pathogenesis of T2D. Dysregulated NK cell responses are associated with an increased risk of cardiovascular disease in patients living with T2D. To provide a comprehensive and systematic evidence-based estimate on the levels of NK cells in patients living with T2D. This systematic review and meta-analysis included 13 studies reporting on 491 adult patients with T2D and 1064 nondiabetic controls. The pooled effect estimates showed increased levels of NK cells in adult patients with T2D compared to controls (MD: 0.03 [− 3.20, 3.26], I2 = 97%, p < 0.00001). Overall, the evidence presented in this systematic review shows that the changes in NK cells in patients living with T2D are still unclear and further studies are needed.

中文翻译：

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成人 2 型糖尿病患者的自然杀伤细胞水平：临床研究的系统回顾和荟萃分析。


慢性免疫激活和高血糖是 2 型糖尿病 (T2D) 的标志，而自然杀伤 (NK) 细胞参与 T2D 的发病机制。 NK 细胞反应失调与 T2D 患者患心血管疾病的风险增加有关。旨在对 T2D 患者的 NK 细胞水平提供全面、系统的循证评估。这项系统回顾和荟萃分析包括 13 项研究，报告了 491 名成年 T2D 患者和 1064 名非糖尿病对照者。汇总效应估计显示，与对照组相比，成年 T2D 患者的 NK 细胞水平升高（MD：0.03 [− 3.20, 3.26]，I2 = 97%，p < 0.00001）。总体而言，本系统评价中提供的证据表明，T2D 患者 NK 细胞的变化仍不清楚，需要进一步研究。