Recent studies have reported the crucial role of stanniocalcin-2 (STC2) in hepatocellular carcinoma; however, its role in head and neck squamous cell carcinoma (HNSCC) remains elusive. In this study, microRNA-206 (miR-206) was predicted to target STC2 gene. The study herein aimed to elucidate the effect of miR-206 on HNSCC by targeting STC2. STC2 was highly expressed in HNSCC tissues and cells. By targeting STC2, miR-206 decreased mRNA and protein expression of STC2. Importantly, our study showed that miR-206 blocked the Akt signaling pathway by inhibiting STC2. Intriguingly, our data from in vitro and in vivo experiments suggested that miR-206 overexpression led to decreased cell proliferation and increased cell apoptosis and autophagy, as well as suppressed tumor growth; whereas, STC2 silencing reversed the effects of miR-206 inhibitor on those biological behaviors. In this study, we investigated the antioncogenic effect of miR-206 on HNSCC by targeting STC2, and highlighted miR-206/STC2 aixs as potential therapeutic targets for HNSCC.

中文翻译：

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microRNA-206通过抑制增殖、促进细胞凋亡和自噬对颈部鳞状细胞癌的抗癌作用。

最近的研究报道了斯钙素 2 (STC2) 在肝细胞癌中的关键作用；然而，它在头颈部鳞状细胞癌 (HNSCC) 中的作用仍然不清楚。在这项研究中，预测 microRNA-206 (miR-206) 靶向 STC2 基因。本文的研究旨在阐明 miR-206 通过靶向 STC2 对 HNSCC 的影响。STC2 在 HNSCC 组织和细胞中高表达。通过靶向 STC2，miR-206 降低了 STC2 的 mRNA 和蛋白表达。重要的是，我们的研究表明 miR-206 通过抑制 STC2 来阻断 Akt 信号通路。有趣的是，我们的体外和体内数据实验表明，miR-206 过表达导致细胞增殖减少，细胞凋亡和自噬增加，并抑制肿瘤生长；然而，STC2 沉默逆转了 miR-206 抑制剂对这些生物学行为的影响。在这项研究中，我们通过靶向 STC2 研究了 miR-206 对 HNSCC 的抗癌作用，并强调了 miR-206/STC2 aixs 作为 HNSCC 的潜在治疗靶点。