Visible Light-Driven α-Alkylation of N-Aryl tetrahydroisoquinolines Initiated by Electron Donor-Acceptor Complexes.,Organic Letters

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Visible Light-Driven α-Alkylation of N-Aryl tetrahydroisoquinolines Initiated by Electron Donor-Acceptor Complexes.
Organic Letters ( IF 4.9 ) Pub Date : 2020-09-09 , DOI: 10.1021/acs.orglett.0c02631
Qing Xia ₁ , Yufei Li ₁ , Xinmin Wang ₁ , Peng Dai ₁ , Hongping Deng ₁ , Wei-Hua Zhang ₁

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The visible light-driven α-alkylation of N-aryl tetrahydroisoquinolines was initiated through electron donor–acceptor complex photochemistry. The reaction can proceed smoothly without the addition of any photocatalysts, transition-metal catalysts, or additional oxidants. The proposed mechanism was supported by various mechanistic studies, and the reactive open-shell alkyl radicals were generally produced from an alkylamine and underwent radical coupling for alkylating a wide range of N-aryl tetrahydroisoquinolines.

中文翻译：

电子给体-受体配合物引发的N-芳基四氢异喹啉的可见光驱动α-烷基化。

N-芳基四氢异喹啉的可见光驱动α-烷基化是通过电子给体-受体复合物光化学引发的。反应可以顺利进行，而无需添加任何光催化剂，过渡金属催化剂或其他氧化剂。各种机理研究支持了所提出的机理，并且反应性开壳烷基通常由烷基胺产生并进行自由基偶联以使多种N-芳基四氢异喹啉烷基化。

更新日期：2020-09-20

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