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Development of Robust Heterogeneous Chiral Rhodium Catalysts Utilizing Acid-base and Electrostatic Interactions for Efficient Continuous-Flow Asymmetric Hydrogenations
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-09-09 , DOI: 10.1021/jacs.0c08109
Yuki Saito 1 , Shu Kobayashi 1
Affiliation  

Heterogeneous chiral Rh catalysts based on acid-base and electro-static interactions have been developed. The robust catalysts demonstrate high activity and selectivity in the continuous-flow asymmetric hydrogenation of a wide variety of enamides and dehy-droamino acids, providing optically active amides without leaching of metal species. The chiral environments can be easily tuned by changing the chiral ligands, demonstrating the high versatility of the heterogeneous catalysts. By applying these efficient catalysts, contin-uous synthesis of several active pharmaceutical ingredient (API) intermediates was achieved.

中文翻译:

利用酸碱和静电相互作用进行高效连续流动不对称氢化反应的稳健多相手性铑催化剂的开发

已经开发了基于酸碱和静电相互作用的多相手性 Rh 催化剂。坚固的催化剂在各种烯酰胺和脱氢氨基酸的连续流动不对称氢化中表现出高活性和选择性,提供光学活性酰胺而不会浸出金属物质。通过改变手性配体可以很容易地调整手性环境,这证明了多相催化剂的高度多功能性。通过应用这些高效催化剂,实现了多种活性药物成分 (API) 中间体的连续合成。
更新日期:2020-09-09
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