Solubility of Salicylic Acid, Salicylamide, and Fenofibrate in Organic Solvents at Low Temperatures,Journal of Chemical & Engineering Data

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Solubility of Salicylic Acid, Salicylamide, and Fenofibrate in Organic Solvents at Low Temperatures
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2020-09-09 , DOI: 10.1021/acs.jced.0c00443
Masoud Sadeghi ₁ , Åke C. Rasmuson ₁

Affiliation

In the present work, the solubility of salicylic acid, salicylamide, and fenofibrate (form I) has been determined in acetone, acetonitrile, ethyl acetate, and methanol in the range of −30 to +10 °C. Salicylic acid and salicylamide have the highest solubility in acetone and the lowest in acetonitrile. Fenofibrate has the highest solubility in ethyl acetate and the lowest in methanol. In all solvents except for acetonitrile, the solubility of salicylic acid is higher than the solubility of the other two compounds. In all solvents except for ethyl acetate, the solubility of fenofibrate is lower than the solubility of the other two compounds. In all cases, the solubility increases with increasing temperature and agrees well with the previously published data at higher temperatures. Finally, an empirical equation is fitted to the experimental data.

中文翻译：

水杨酸，水杨酰胺和非诺贝特在低温下在有机溶剂中的溶解度

在本工作中，已确定水杨酸，水杨酰胺和非诺贝特（形式I）在丙酮，乙腈，乙酸乙酯和甲醇中的溶解度为-30至+10°C。水杨酸和水杨酰胺在丙酮中的溶解度最高，而在乙腈中的溶解度最低。非诺贝特在乙酸乙酯中的溶解度最高，在甲醇中的溶解度最低。在除乙腈之外的所有溶剂中，水杨酸的溶解度均高于其他两种化合物的溶解度。在除乙酸乙酯之外的所有溶剂中，非诺贝特的溶解度均低于其他两种化合物的溶解度。在所有情况下，溶解度都随着温度的升高而增加，并且与先前公布的更高温度下的数据非常吻合。最后，将经验方程拟合到实验数据。

更新日期：2020-10-08

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