Mesenchymal stem cells (MSCs) are a class of adult stem cells derived from the mesoderm. They can self-renew, have multidirectional differentiation potential, and can differentiate into a variety of mesenchymal tissues. MSCs can produce a large number of exosomes, which can mediate information exchange and transmission between cells in the tumor microenvironment under conditions of rest or stress. Recent studies have reported conflicting findings regarding the effect of MSC-derived exosomes on tumors. Some studies have suggested that MSC-derived exosomes can promote tumor growth and metastasis, but others have reported that they can inhibit tumor cell growth. Here, we investigate the two sides of the debate regarding the effect of MSC-derived exosomes on tumors and analyze the reasons for the divergent findings.

中文翻译：

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MSC衍生的外来体在肿瘤发展中的双重作用。

间充质干细胞（MSC）是一类源自中胚层的成年干细胞。它们可以自我更新，具有多向分化潜能，并且可以分化为多种间充质组织。MSC可以产生大量的外泌体，它们可以在休息或压力条件下介导肿瘤微环境中细胞之间的信息交换和传递。最近的研究报告了关于MSC来源的外泌体对肿瘤作用的矛盾发现。一些研究表明，MSC衍生的外泌体可以促进肿瘤的生长和转移，但是其他研究则报道它们可以抑制肿瘤细胞的生长。在这里，我们调查关于MSC来源的外泌体对肿瘤的影响的辩论的两个方面，并分析导致不同发现的原因。