Inflammation can cause various chronic diseases like inflammatory bowel diseases. Various food protein-derived bioactive peptides (BAPs) with anti-inflammatory activity have the potential to manage these diseases. The aim of this paper is to overview the mechanisms and the molecular targets of BAPs to exert anti-inflammatory activity. In this review, the in vitro and in vivo effects of BAPs on intestinal inflammation are highlighted. The mechanism, pathways, and future perspectives of BAPs as the potential sources of therapeutic treatments to alleviate intestinal inflammation are provided, including nuclear factor-κB, mitogen-activated protein kinase, Janus kinase-signal transducer and activator of transcription, and peptide transporter 1 (PepT1), finding that PepT1 and gut microbiota are the promising targets for BAPs to alleviate the intestinal inflammation. This review provides a comprehensive understanding of the role of dietary BAPs in attenuating inflammation and gives a novel direction in nutraceuticals for people or animals with intestinal inflammation.

中文翻译：

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食品蛋白衍生的生物活性肽对抗慢性肠道炎症的潜力。


炎症可引起各种慢性疾病，例如炎症性肠病。各种具有抗炎活性的食品蛋白衍生生物活性肽（BAP）有可能治疗这些疾病。本文的目的是概述 BAP 发挥抗炎活性的机制和分子靶点。在这篇综述中，重点介绍了 BAP 对肠道炎症的体外和体内影响。提供了 BAP 作为减轻肠道炎症的潜在治疗来源的机制、途径和未来前景，包括核因子 - κ B、丝裂原激活蛋白激酶、Janus 激酶信号转导器和转录激活剂以及肽转运蛋白1 (PepT1)，发现 PepT1 和肠道微生物群是 BAP 缓解肠道炎症的有希望的靶标。这篇综述全面了解了膳食 BAP 在减轻炎症方面的作用，并为患有肠道炎症的人或动物的营养保健品提供了新的方向。