To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in-situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. Biopsies were completely sectioned and on average 146 serial sections/patient were stained for VZV glycoprotein E. Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific PCR on adjacent sections. This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

中文翻译：

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在有或没有巨细胞动脉炎的前部缺血性视神经病患者的颞动脉活检中，没有水痘带状疱疹病毒感染的证据。

为了检验水痘带状疱疹病毒（VZV）感染有助于颞动脉炎发病的假说，对38例前缺血性视神经病变（AION）患者的颞动脉活检进行了综合原位分析，包括14例（37％）巨细胞动脉炎。活检完全切片，平均每人146个连续切片进行VZV糖蛋白E染色。38例AION患者中有4例显示VZV糖蛋白E染色，但未通过在相邻切片上染色VZV IE63蛋白和VZV特异性PCR证实VZV感染。这项研究驳斥了VZV与有或没有巨细胞动脉炎的AION偶然相关的前提。