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Embryonic Exposure to Ethanol Increases Anxiety-Like Behavior in Fry Zebrafish.
Alcohol and Alcoholism ( IF 2.1 ) Pub Date : 2020-09-04 , DOI: 10.1093/alcalc/agaa087
Jaquelinne Pinheiro-da-Silva 1 , Thais Agues-Barbosa 1 , Ana Carolina Luchiari 1
Affiliation  

Fetal alcohol spectrum disorder (FASD) is an umbrella term to describe the effects of ethanol (Eth) exposure during embryonic development, including several conditions from malformation to cognitive deficits. Zebrafish (Danio rerio) are a translational model popularly applied in brain disorders and drug screening studies due to its genetic and physiology homology to humans added to its transparent eggs and fast development. In this study, we investigated how early ethanol exposure affects zebrafish behavior during the initial growth phase.

中文翻译:

胚胎暴露于乙醇会增加鱼苗斑马鱼的焦虑样行为。

胎儿酒精谱系障碍 (FASD) 是一个总称,用于描述胚胎发育过程中乙醇 (Eth) 暴露的影响,包括从畸形到认知缺陷的几种情况。斑马鱼 ( Danio rerio ) 是一种广泛应用于脑部疾病和药物筛选研究的转化模型,因为它与人类的遗传和生理同源性添加到其透明的卵子中,并且发育速度快。在这项研究中,我们调查了早期乙醇暴露如何影响斑马鱼在初始生长阶段的行为。
更新日期:2020-10-26
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