Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource.,Nature Genetics

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Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource.
Nature Genetics ( IF 31.7 ) Pub Date : 2020-09-09 , DOI: 10.1038/s41588-020-0693-3
Stephanie Portelli _{1,

2} , Moshe Olshansky _{1,

2} , Carlos H M Rodrigues _{1,

2} , Elston N D'Souza _{1,

2} , Yoochan Myung _{1,

2} , Michael Silk _{1,

2} , Azadeh Alavi _{1,

2} , Douglas E V Pires _{1,

2,

3} , David B Ascher _{1,

2,

4}

Affiliation

The emergence of the COVID-19 pandemic has spurred a global rush to uncover basic biological mechanisms to inform effective vaccine and drug development. Despite the novelty of the virus, global sequencing efforts have already identified genomic variation across isolates. To enable easy exploration and spatial visualization of the potential implications of SARS-CoV-2 mutations in infection, host immunity and drug development, we have developed COVID-3D (http://biosig.unimelb.edu.au/covid3d/).

中文翻译：

利用COVID-3D在线资源探索SARS-CoV-2中遗传变异的结构分布。

COVID-19大流行的出现刺激了全球范围内的热衷，以发现基本的生物学机制来为有效的疫苗和药物开发提供信息。尽管有这种病毒的新颖性，但全球测序工作已经确定了分离株之间的基因组变异。为了使SARS-CoV-2突变在感染，宿主免疫和药物开发中的潜在影响易于探索和空间可视化，我们开发了COVID-3D（http://biosig.unimelb.edu.au/covid3d/）。

更新日期：2020-09-10

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