Biodegradable hemostatic gauze used for surgical hemostasis has attracted great interest due to its excellent compliance and local anti-inflammatory and therapeutic effects when combined with drugs. Herein, we demonstrate the successful fabrication of water-soluble absorbed cellulose hemostatic material by introducing a biocompatible hydroxyethyl cellulose (HEC) hemostasis gauze into doxorubicin-loaded in situ gel (GEL(DOX)) for the prevention of breast cancer recurrence after surgical tumor resection. The present results show that HEC has a shorter metabolic period, no anaphylaxis and peripheral nerve toxicity, and possesses more advantages than oxidative regenerated cellulose hemostasis gauze, a commercially available product in market. HEC is of the physical hemostasis in mechanism, which does not induce physiological hemostasis and hemolysis. In addition, the combination of HEC with GEL(DOX) not only stops the bleeding efficiently, but also effectively reduces the proliferation of tumor with no cardiac toxic and bone marrow suppression. After treatment, the tumor inhibition rate is up to 90%, resulting in prolonged survival time to 58 days. In conclusion, HEC hemostatic gauze has a broad prospect in clinical application due to its perfect biocompatibility, and we envision that it is a new strategy for the prevention of breast cancer to implant HEC hemostatic gauze containing GEL(DOX) at the postoperative site after surgery.

中文翻译：

---

载有阿霉素的原位凝胶与生物相容性羟乙基纤维素止血纱布结合以控制药物释放并预防乳腺癌术后复发。

用于外科手术止血的可生物降解的止血纱布因其出色的顺应性以及与药物结合使用时的局部抗炎和治疗作用而引起了人们的极大兴趣。本文中，我们通过将生物相容性羟乙基纤维素（HEC）止血纱布引入载有阿霉素的原位凝胶（GEL（DOX））中以预防外科肿瘤切除术后乳腺癌的复发，证明了水溶性吸收性纤维素止血材料的成功制造。目前的结果表明，与市场上可买到的氧化再生纤维素止血纱布相比，HEC的代谢周期更短，没有过敏反应和周围神经毒性，并且具有更多的优势。HEC具有物理止血的机制，其不引起生理止血和溶血。此外，HEC与GEL（DOX）的组合不仅可以有效地止血，而且可以有效地减少肿瘤的扩散，而没有心脏毒性和骨髓抑制作用。治疗后，肿瘤抑制率高达90％，从而使生存时间延长至58天。总之，HEC止血纱布由于其完美的生物相容性而在临床上具有广阔的应用前景，并且我们认为，在手术后的术后部位植入含GEL（DOX）的HEC止血纱布是预防乳腺癌的一种新策略。 。导致生存时间延长至58天。总之，HEC止血纱布由于其完美的生物相容性而在临床上具有广阔的应用前景，并且我们认为在手术后的术后部位植入含有GEL（DOX）的HEC止血纱布是预防乳腺癌的一种新策略。 。导致生存时间延长至58天。总之，HEC止血纱布由于其完美的生物相容性而在临床上具有广阔的应用前景，并且我们认为，在手术后的术后部位植入含GEL（DOX）的HEC止血纱布是预防乳腺癌的一种新策略。 。